Hereditary Spastic Paraplegia Stem Cell Treatment

That is me who has undertaken a treatment for my hereditary spastic paraparesis.

Hereditary spastic paraplegia stem cell treatment.

To evaluate its antispastic action gabapentin was tested in a double blind prospective crossover placebo controlled trial in patients with spg4 linked hereditary spastic paraplegia. Mutations in spast are a major cause of adult onset autosomal dominant hsp. Physical therapy is extremely important to improve range of motion of the involved extremity as well as strengthening of the muscles. I live in turkey.

The hereditary spastic paraplegia proteins nipa1 spastin and spartin are inhibitors of mammalian bmp signalling. As of now there is no clear cut treatment for hereditary spastic paraplegia or strumpell lorraine syndrome but some of the treatments mentioned are found to be useful. Ten adult patients were included and were randomly allocated to two treatment regimens. A medical team which was established by my father who is a pt physician implemented the treatment.

A patient derived stem cell model of hereditary spastic paraplegia with spast mutations. Hereditary spastic paraplegia hsp leads to progressive gait disturbances with lower limb muscle weakness and spasticity. Upper motor neurons in the brain and spinal cord deliver signals to the lower motor neurons which in turn carry messages to the muscles. The first received gabapentin for a period of 2 months which was followed by a washout period of 10 days a drug free interval of 1 month and finally placebo therapy for 2 months.

Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. Spastin the protein encoded by spast is a microtubule severing protein that is enriched in the distal axon of corticospinal motor neurons which degenerate in hsp patients. Neurodegeneration and microtubule dynamics. The hsp research foundation is an incorporated registered australian charity that facilitates and funds research to find an effective treatment.

15 days passed and waiting if it will work for me. My disease may be originated by genes. Stem cells were derived from my belly lipids and then injected into my legs to find their way. The second group received the same.

We are using stem cells developed from nasal tissue samples of people with hsp to study the disease to work out what is happening in the diseased cells to identify potential drug treatments and then to test them in depth for their ability to restore or compensate for impaired function caused by the hsp mutation.